For an oocyte to get ready for fertilization and progress into an embryo, the appropriate list of genes really should be turned on. Namekawa suspected that this pre-programming of your oocyte genome takes place in several levels — the first one beginning within the time a female is born. He thought that chromatin remodeling proteins did much of this do the job, by shifting spools all around.
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In 2022, they discovered that a set of proteins named Polycomb repressive elaborate 1 (PRC1) assists silence hundreds of genes throughout the time of start by modifying the framework of spools.
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